Reversible covalent protein-binding molecules, methods of making and uses thereof
AssigneeMcMaster University
InventorsAnthony Rullo, Tomas Frankovich, Jonathan Bramson, Nickolas Serniuk
Life of this patent
Estimating the term…
Abstract
This application is directed to proximity inducing molecules (PIMs). More particularly, the present application relates to protein-binding molecules in combination with covalent labeling domains that induce the formation of stable ternary complexes via reversible covalent bonds, and methods of making and uses thereof. Included are compounds of Formula (I), Formula (II) or Formula (III) or a pharmaceutically acceptable salt and/or solvate thereof, and compositions comprising the same.
Claims20
A compound of Formula (I), Formula (II) or Formula (III) or a pharmaceutically acceptable salt and/or solvate thereof,
- wherein PBD1 and PBD2 are each independently a protein binding domain (PBD) and CLD1 and CLD2 are each independently a covalent labeling domain (CLD), and L1, L2 and L3 are each independently a linker group;
- n=0 or 1 and m=0 or 1, wherein at least one of n and m is 1,
- wherein PBD1 selectively binds to a first target protein and PBD2 selectively binds to a second target protein, and wherein CLD1, if present, comprises a functional group that, upon binding of PBD1 to the first target protein, forms a reversible covalent bond with a nucleophilic group in the first target protein and CLD2, if present, comprises a functional group that, upon binding of PBD2 to the second target protein, forms a reversible covalent bond with a nucleophilic group in the second target protein.
Dependencies are inferred from the claim text.