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US 2026/0224711 A1Published application
ENHANCING BRAIN PERMEABILITY AND ACTIVITY OF GLUCOSYLCERAMIDASE (GCase) PROSNA FOR NEURODEGENERATIVE DISEASES
AssigneeNorthwestern University
InventorsChad A. Mirkin, Sergej Kudruk, Julianna Nicole Bourgeois, Max Everett Distler, Caroline Danielle Kusmierz
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Abstract
The present disclosure provides protein-core spherical nucleic acids (ProSNAs) and strategies for delivering glucosyl-ceramidase (GCase) proteins into cells (e.g., brain cells). In some aspects the disclosure provides a protein-core spherical nucleic acid (ProSNA) comprising: (a) a protein core that comprises a glucosylceramidase (GCase); and (b) a shell of oligonucleotides attached to the protein core.
Claims23
A protein-core spherical nucleic acid (ProSNA) comprising:
- (a) a protein core that comprises a glucosylceramidase (GCase);
- and
- (b) a shell of oligonucleotides attached to the protein core.
Dependencies are inferred from the claim text.