Synthesizing drug-organic-acid-anhydride conjugates without using coupling reagent
AssigneeCnpharm Co., Ltd.
InventorsHojun Kim, Kwang Sik Park, Guen-Woo Jin
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Abstract
Synthesizing a drug-organic-acid-anhydride conjugate using docetaxel as a drug, including: mixing aconitic anhydride with a chlorinating reagent to produce a first mixture; dissolving the first mixture in an organic solvent to produce a dissolved mixture; stirring the dissolved mixture; evaporating the organic solvent from the dissolved mixture to produce a second mixture; washing the second mixture with an impurity remover to remove impurities and to produce an aconitic anhydride chloride solution; and mixing the docetaxel with the aconitic anhydride chloride solution to produce the drug-organic-acid-anhydride conjugate.
Claims1
A method for synthesizing a drug-organic-acid-anhydride conjugate using docetaxel as a drug, the method comprising:
- mixing aconitic anhydride with a chlorinating reagent to produce a first mixture;
- dissolving the first mixture in an organic solvent to produce a dissolved mixture;
- stirring the dissolved mixture;
- evaporating the organic solvent from the dissolved mixture to produce a second mixture;
- washing the second mixture with an impurity remover to remove impurities and to produce an aconitic anhydride chloride solution;
- and
- mixing the docetaxel with the aconitic anhydride chloride solution to produce the drug-organic-acid-anhydride conjugate.
Dependencies are inferred from the claim text.