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US 2026/0224688 A1Published application
Helper lipids for nucleic acid delivery
AssigneeSanofi Pasteur Limited
InventorsHongfeng DENG, Frank DEROSA, Shrirang KARVE, Neha KAUSHAL
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Abstract
Provided herein are a class of helper lipid compounds of use in the in vivo delivery of therapeutic agents, such as nucleic acids.
Claims20
A compound having a structure according to Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Y is selected from optionally substituted C2-C6 alkylene or optionally substituted C4-C6 alkenylene;
- Ra is absent, or Ra is optionally substituted C1-C10 alkyl, wherein, when Ra is present, the nitrogen to which Ra is bonded bears a positive charge;
- each R1 is independently selected from hydrogen or optionally substituted C1-C10 alkyl;
- each R2 is independently selected from:
- (i) optionally substituted C4-C24 alkyl, optionally substituted C4-C24 alkenyl, and optionally substituted C4-C24 alkynyl;
- wherein each RA is independently selected from optionally substituted C1-C31 alkyl, optionally substituted C2-C31 alkenyl, and optionally substituted C2-C31 alkynyl;
- and
- wherein each ZA is independently selected from optionally substituted C1-C10 alkylene and optionally substituted C2-C10 alkenylene;
- wherein each RB is independently selected from optionally substituted C1-C31 alkyl, optionally substituted C2-C31 alkenyl, and optionally substituted C2-C31 alkynyl;
- and
- wherein each ZB is independently selected from optionally substituted C1-C10 alkylene and optionally substituted C2-C10 alkenylene.
9 more elements
A compound selected from those listed in Table A, or a pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.