Compositions for inducing or rescuing glycolysis and methods of use thereof
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorAbhinav Acharya
Life of this patent
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Abstract
The present invention provides polymers, particles (e.g., microparticles or particles), and compositions thereof for inducing an immune response, preventing or treating a metabolic inhibition in a subject, preventing or treating a disease or disorder, such as cancer, and/or adoptive T cell therapy. The present invention additionally provides kits that find use in the practice of the methods of the invention.
Claims28
A composition comprising a particle, wherein the particle comprises:
- a) a nucleic acid molecule or a fragment or variant thereof comprising a nucleotide sequence that encodes at least one antigen or a fragment or variant thereof, and
- b) a compound comprising at least one selected from the group consisting of:
- i) a metabolite or a derivative or a polymer thereof;
- and
- ii) the structure of Formula (I)
- or a derivative or a pharmaceutical acceptable salt thereof,
- wherein each occurrence of X1 and X2 is independently C═R1, CR2, or CR3R4;
- each occurrence of X3 and X4 is independently C═R1 or CR3R4;
- each occurrence of Xs is independently O, S, C═R1, CR3R4, NR2, PR2, or P(═R1)(R2);
- the bond between X1 and X2 is a single bond or a double bond;
- wherein when the bond between X1 and X2 is a single bond, X1 and X2 are each independently C═R1 or CR3R4, and when the bond between X1 and X2 is a double bond X1 and X2 are each CR2;
- each occurrence of R1 is independently selected from the group consisting of O, NH and S;
- each occurrence of R2, R3, and R4 is independently selected from the group consisting of hydrogen, hydroxyl, carboxyl, alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
- each occurrence of m is independently an integer represented by 0, 1, 2, or 5;
- each occurrence of p is independently an integer from 1 to 50;
- and
- each occurrence of n is independently an integer from 1 to 1000.
5-7. (canceled)
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18-20. (canceled)
23-26. (canceled)
A method of preventing or treating a disease or disorder, a metabolic inhibition of at least one cell, or a combination thereof in a subject in need thereof, wherein the method comprises administering a therapeutically effective amount of the composition comprising at least one particle,
- wherein the particle comprises:
- a) a compound comprising at least one selected from the group consisting of:
- i) a metabolite or a derivative or a polymer thereof;
- and
- ii) the structure of Formula (I)
- or a derivative or a pharmaceutical acceptable salt thereof,
- wherein each occurrence of X1 and X2 is independently C═R1, CR2, or CR3R4;
- each occurrence of X3 and X4 is independently C═R1 or CR3R4;
- each occurrence of X5 is independently O, S, C═R1, CR3R4, NR2, PR2, or P(═R1)(R2);
- the bond between X1 and X2 is a single bond or a double bond;
- wherein when the bond between X1 and X2 is a single bond, X1 and X2 are each independently C═R1 or CR3R4, and when the bond between X1 and X2 is a double bond X1 and X2 are each CR2;
- each occurrence of R1 is independently selected from the group consisting of O, NH and S;
- each occurrence of R2, R3, and R4 is independently selected from the group consisting of hydrogen, hydroxyl, carboxyl, alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
- each occurrence of m is independently an integer represented by 0, 1, 2, or 5;
- each occurrence of p is independently an integer from 1 to 50;
- and
- each occurrence of n is independently an integer from 1 to 1000;
- and
- b) at least one selected from the group consisting of
- i) a nucleic acid molecule or a fragment or variant thereof comprising a nucleotide sequence that encodes at least one antigen or a fragment or variant thereof, and
- ii) an antigen or a fragment or variant thereof.
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41-42. (canceled)
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Dependencies are inferred from the claim text.