Cardiac dilatation function improving agent, and method for screening for cardiac dilatation function improving agent
AssigneeKeio University
InventorsMasaki IEDA, Yu YAMADA, Taketaro SADAHIRO
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Abstract
The cardiac diastolic function-improving agent according to an embodiment of the present invention comprises a polynucleotide encoding a reprogramming factor polypeptide Gata4.
Claims16
A cardiac diastolic function-improving agent comprising only a polynucleotide encoding a reprogramming factor polypeptide Gata4 as a reprogramming factor.
A cardiac diastolic function-improving agent comprising a factor that upregulates the expression of Gata4 gene.
A cardiac diastolic function-improving agent comprising a factor that increases the expression level of Gata4 gene in cardiac fibroblasts.
A screening method for a cardiac diastolic function-improving agent, comprising:
- contacting a test substance with fibroblasts;
- and
- evaluating the expression of only Gata4 gene in the fibroblasts as a reprogramming factor.
A method for improving cardiac diastolic function, comprising administering a polynucleotide encoding a reprogramming factor polypeptide Gata4 as a reprogramming factor to a subject in need therefore, thereby improving cardiac diastolic function in the subject.
Dependencies are inferred from the claim text.