Polynucleotides and use of same for wound healing
AssigneeRambam Med-Tech Ltd.
InventorsMogher KHAMAISI, Salim HADAD
Life of this patent
Estimating the term…
Abstract
Methods for treating a wound in a subject in need thereof, by a miR molecule, or by a fibroblast expressing the miR molecule, from the miR-1 family, the precursor thereof, or the mature product thereof, are provided. Further provided are pharmaceutical compositions including the miR molecule, or a fibroblast expressing the miR molecule, selected from hsa-miR-1-3p, hsa-mir-1-1, and hsa-miR-1-2, for use in treatment of a wound in a subject in need thereof.
Claims23
A method of treating a wound in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of a pharmaceutical composition comprising an agent capable of increasing expression, abundance, or both, of a micro-RNA (miR) molecule belonging to miR-1 family in said subject, thereby treating a wound in said subject.
A method for treating a wound in a subject in a need thereof, the method comprising the steps of:
- (a) providing a composition comprising a fibroblast being characterized by increased expression, abundance, or both, of a miR molecule from miR-1 family;
- and,
- (b) administering a therapeutically effective amount of said composition from step (a) to said subject,
- thereby treating a wound in the subject.
-25. (canceled)
A pharmaceutical composition comprising a modified fibroblast being characterized by increased expression, abundance, or both, of a miR molecule belonging to miR-1 family, compared to a control fibroblast.
-29. (canceled)
-32. (canceled)
Dependencies are inferred from the claim text.