Memantyl urea derivative, preparation method thereof, and use thereof in preparation of drug for treating soluble epoxide hydrolase-mediated disease

A memantyl urea derivative, having a structure selected from the group consisting of Formula A and Formula B:

• wherein in Formula A and Formula B,
• R1 and R2 each are independently selected from the group consisting of —H, —OH, —NH2, —SH, —CN, a halogen group, alkyl, alkoxy, aryl, and heteroaryl;
• R3 is selected from the group consisting of —H, —OH, —NH2, —SH, —CN, a halogen group, alkyl, and alkoxy;
• R4 is selected from the group consisting of —OH, —NH2, hydroxylamino, alkyl-substituted amino, alkoxy-substituted amino, alcohol group-substituted amino, phenyl-substituted amino,
• naphthyl-substituted amino, and
• Y is selected from the group consisting of —H wherein
• R5 is selected from the group consisting of alkyl, alkoxy, and a heterocyclic group, the alkyl being selected from the group consisting of chain alkyl and cycloalkyl;
• and
• R6 is selected from the group consisting of alkyl-substituted amino and alcohol group-substituted alkyl;
• X is selected from the group consisting of —CH2— an
• L is absent or —NH—;
• D is selected from the group consisting of
• n is 1 or 2;
• and
• Z and M each are independently selected from the group consisting of ═O and ═S.