Treatment for auditory disorders
OwnerDouglas Bennion, Marlan Hansen +2inventors
InventorsDouglas Bennion, Marlan Hansen, Zachary Urdang, Carolina Chu
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Abstract
Provided herein are medical treatments for auditory disorders, specifically methods utilizing angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs), angiotensin II type 2 receptor (AT2R) agonists, and Mas receptor (MasR) agonists to prevent and treat conditions such as hearing loss, tinnitus, and Meniere's Disease. The disclosed methods address the lack of FDA-approved therapies for these disorders by repurposing safe, cost-effective medications traditionally used for hypertension and other conditions.
Claims24
A method to prevent or treat an auditory disorder comprising administering to a subject in need thereof an angiotensin receptor blocker (ARB), an angiotensin converting enzyme (ACE) inhibitor, an angiotensin II type 2 receptor (AT2R) agonist, a Mas receptor (MasR) agonist or a combination thereof, wherein the ARB is not telmisartan.
A method to prevent or treat tinnitus, Meniere's Disease or dizziness/vertigo comprising administering to a subject in need thereof an angiotensin receptor blocker (ARB), a calcium channel blocker (CCB), an angiotensin converting enzyme (ACE) inhibitor, an angiotensin II type 2 receptor (AT2R) agonist, a Mas receptor (MasR) agonist or a combination thereof.
A method to prevent or treat a shift in auditory brainstem response (ABR) from noise induced trauma comprising administering to a subject in need thereof an angiotensin receptor blocker (ARB), an angiotensin converting enzyme inhibitors (ACEi), an angiotensin II type 2 receptor (AT2R) agonist, a Mas receptor agonist or a combination thereof.
Dependencies are inferred from the claim text.