Methods of preparing multiphase statin and omega-3 fatty acid soft capsule formulations
AssigneeCatalent Ontario Limited
InventorsPeter Draper, James Draper, Beth Okutan
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Abstract
Methods of preparing multi-phase soft gelatin dosage forms comprising at least one preformed solid dosage form comprising a statin compound and at least one liquid fill phase comprising Omega-3 fatty acids. The multi-phase soft gelatin dosage forms combine at least one solid dosage form and at least one liquid phase for single ingestion. The solid phase, liquid phase and/or coatings may include additional active pharmaceutical ingredients, nutraceuticals, nutritional supplements, or therapeutic substances, functional excipients or combinations thereof.
Claims29
A multi-phase soft gelatin capsule for oral administration, the soft gelatin capsule comprising:
- at least one preformed solid dosage form comprising a statin atorvastatin or a pharmaceutical acceptable salt thereof;
- and
- at least one liquid fill phase comprising omega-3 fatty acids;
- wherein the at least one solid dosage form and the at least one liquid fill phase are independently introduced in the soft gelatin capsule.
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Dependencies are inferred from the claim text.