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US 2026/0224490 A1Published application
Co-crystals with thin-film freeze-drying process to enhance delivery
AssigneeBoard of Regents, The University of Texas System
InventorsRobert O. WILLIAMS, III, Jay I. PETERS, Tuangrat PRAPHAWATVET, Sawittree SAHAKIJPIJARN, Chaeho MOON
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Abstract
The present disclosure provides co-crystals of an active pharmaceutical ingredient and a co-former. The co-former may be either an excipient or a second active pharmaceutical ingredient. These particular co-crystals may be made through thin-film freeze-drying methods. Pharmaceutical compositions comprising these co-crystals may be used in the treatment of a disease or disorder.
Claims243
A method of providing a pharmaceutical composition comprising:
- (A) admixing a drug solution comprising an active pharmaceutical ingredient and a co-former to form a co-crystal solution;
- (B) admixing the co-crystal solution with an excipient to form a precursor pharmaceutical composition;
- (C) depositing the precursor pharmaceutical composition onto a surface, wherein the surface is at a surface temperature below the freezing point of the precursor pharmaceutical composition to produce composite drug particles;
- and
- (D) collecting the composite drug particles from the surface to thereby provide the pharmaceutical composition.
2 more elements
A pharmaceutical composition comprising:
- (A) an active pharmaceutical ingredient;
- (B) a co-former;
- and
- (C) an excipient;
- wherein the active pharmaceutical ingredient and the co-former forms a co-crystal, the co-crystal and the excipient are formulated into a single particle, and the co-crystal of the active pharmaceutical ingredient and the co-former have particles from about 500 nm to about 15 μm.
2 more elements
Dependencies are inferred from the claim text.