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US 2026/0224110 A1Published application
Magnetic resonance guided selection of sensory stimulus control commands for tinnitus
AssigneeKoninklijke Philips N.V.
InventorsRaymond van Ee, Maria Estrella Mena Benito
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Abstract
Disclosed herein is a medical system (100, 400) comprising a magnetic resonance imaging system (102) configured for acquiring k-space data (152, 156) of a brain of a subject (118) and a sensory stimulus system (122) configured for providing audio stimulation to the subject. Functional magnetic resonance imaging is used to select at least one subject specific sensory stimulus control command (166) from a predetermined set of sensory stimulus control commands 160 that maximize a change in neural activity in the at least one abnormal stimulus region of the audio cortex of the subject.
Claims15
A medical system comprising:
- a magnetic resonance imaging system configured for acquiring k-space data of a brain of a subject;
- a sensory stimulus system configured to provide audio stimulation to the subject;
- a memory configured to store machine executable instructions and pulse sequence commands, wherein the pulse sequence commands are configured to control the magnetic resonance imaging system to acquire the k-space data according to a functional magnetic resonance imaging protocol configured to measure brain activity in an audio cortex of the subject;
- a computational system configured to control the medical system, wherein execution of the machine executable instructions causes the computational system to:
- receive a tonotopic mapping of an audio cortex mapping of the subject, wherein the tonotopic mapping comprises a spatial mapping descriptive of auditory frequency sensitive responses for the subject;
- identify at least one abnormal stimulus region within the tonotopic mapping;
- acquire baseline k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands;
- reconstruct a baseline functional magnetic resonance image from the baseline k-space data;
- wherein execution of the machine executable instructions causes the computational system to repeatedly:
- acquire reference k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands;
- control the sensory stimulus system with one of a predetermined set of sensory stimulus control commands during acquisition of the reference k-space data, wherein each of the predetermined set of sensory stimulus control commands are configured to control the sensory stimulus system to present a predetermined audio stimulation to the subject;
- reconstruct a reference functional magnetic resonance image from the reference k-space data;
- and
- assign a numerical score to the one of the predetermined set of sensory stimulus control commands by detecting a change in neural activity in the at least one abnormal stimulus region between the baseline functional magnetic resonance image and the reference functional magnetic resonance image, the score being representative of a decrease or an increase in neural activity in the at least one abnormal stimulus region;
- and
- wherein execution of the machine executable instructions further causes the computational system to construct at least one subject specific sensory stimulus control command by selecting sensory stimulus control commands from the predetermined set of sensory stimulus control commands that maximize a change in neural activity in the at least one abnormal stimulus region using the numerical score for each repetition of the predetermined set of sensory stimulus control commands.
13 more elements
A method of operating a medical system, wherein the medical system comprises a magnetic resonance imaging system configured to acquire k-space data of a brain of a subject, wherein the medical system further comprises a sensory stimulus system configured to provide audio stimulation to the subject,
- wherein the method comprises:
- receiving a tonotopic mapping of an audio cortex mapping of the subject, wherein the tonotopic mapping comprises a spatial mapping descriptive of auditory frequency sensitive responses for the subject;
- identifying at least one abnormal stimulus region within the tonotopic mapping;
- acquiring baseline k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands;
- reconstructing a baseline functional magnetic resonance image from the baseline k-space data;
- wherein the method further comprises repeatedly:
- acquiring reference k-space data by controlling the magnetic resonance imaging system with pulse sequence commands, wherein the pulse sequence commands are configured to control the magnetic resonance imaging system to acquire the k-space data according to a functional magnetic resonance imaging protocol for measuring brain activity in an audio cortex of the subject;
- controlling the sensory stimulus system with one of a predetermined set of sensory stimulus control commands during acquisition of the reference k-space data, wherein each of the predetermined set of sensory stimulus control commands are configured to control the sensory stimulus system to present a predetermined audio stimulation to the subject;
- reconstructing a reference functional magnetic resonance image from the reference k-space data;
- and
- assigning numerical score to the one of a predetermined set of sensory stimulus control commands by detecting a change in neural activity in the at least one abnormal stimulus region between the baseline functional magnetic resonance image and the reference functional magnetic resonance image, the score being representative of a decrease or an increase in neural activity in the at least one abnormal stimulus region;
- and
- wherein the method further comprises constructing at least one subject specific sensory stimulus control command by selecting sensory stimulus control commands from the predetermined set of sensory stimulus control commands that maximize a change in neural activity in the at least one abnormal stimulus region using the numerical score for each repetition of the predetermined set of sensory stimulus control commands.
10 more elements
A computer program comprising machine executable instructions stored on a non-transitory computer readable medium for execution by a computational system configured to control a medical system, wherein the medical system comprises a magnetic resonance imaging system configured to acquire k-space data of a brain of a subject, wherein the medical system further comprises a sensory stimulus system configured to provide audio stimulation to the subject;
- wherein execution of the machine executable instructions causes the computational system to:
- receive a tonotopic mapping of an audio cortex mapping of the subject, wherein the tonotopic mapping comprises a spatial mapping descriptive of auditory frequency sensitive responses for the subject;
- identify at least one abnormal stimulus region within the tonotopic mapping;
- acquire baseline k-space data by controlling the magnetic resonance imaging system with pulse sequence commands, wherein the pulse sequence commands are configured to control the magnetic resonance imaging system to acquire the k-space data according to a functional magnetic resonance imaging protocol for measuring brain activity in an audio cortex of the subject;
- reconstruct a baseline functional magnetic resonance image from the baseline k-space data;
- wherein execution of the machine executable instructions causes the computational system to repeatedly:
- acquire reference k-space data by controlling the magnetic resonance imaging system with the pulse sequence commands;
- control the sensory stimulus system with one of a predetermined set of sensory stimulus control commands during acquisition of the reference k-space data, wherein each of the predetermined set of sensory stimulus control commands are configured to control the sensory stimulus system to present a predetermined audio stimulation to the subject;
- reconstruct a reference functional magnetic resonance image from the reference k-space data;
- and
- assign a numerical score to the one of a predetermined set of sensory stimulus control commands by detecting a change in neural activity in the at least one abnormal stimulus region between the baseline functional magnetic resonance image and the reference functional magnetic resonance image, the score being representative of a decrease or an increase in neural activity in the at least one abnormal stimulus region;
- and
- wherein execution of the machine executable instructions further causes the computational system to construct at least one subject specific sensory stimulus control command by selecting sensory stimulus control commands from the predetermined set of sensory stimulus control commands that maximize a change in neural activity in the at least one abnormal stimulus region using the numerical score for each repetition of the predetermined set of sensory stimulus control commands.
10 more elements
Dependencies are inferred from the claim text.