Biomarkers for assessing the effect of drugs in pathological disorders
AssigneeDermAb. io
InventorsMiriam ORON, Meital PORTUGAL COHEN, Guy SHALOM
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to kits, substrate materials and methods for individualizing a treatment regimen for a subject with a disease and/or monitoring disease progression in the subject, the method comprising calculating probability of treatment success for one or more treatment regimens, the probability of treatment success calculation is based on expression of at least one biomarker determined in one or more skin samples collected from the subject.
Claims48
A method for treating for a subject suffering from a skin disease, the method comprising
- (a) determining an expression of at least one biomarker selected from the group consisting of IL-1a, IL-1RA, IL-10, Albumin, Kallikrein (KLK) protein family (e.g. KLK5), IL-4, IL-5, IL-22, IL-33, TLSP, Matrix metalloproteinases (MMPs) protein family (e.g. MMP-9), IL-8, The chemokine (C—X—C motif) ligand family (e.g. CXCL2), IL-1b, IL-6 FGF basic, ORAC, GSH, UA or any combination thereof in at least one skin sample collected from said subject or in a skin area of said subject,
- (b) calculating a probability of treatment success for one or more treatment regimens, based on the expression of the at least one biomarker
- (c) classifying the subject as a responder or non-responder to the treatment regimen based on said calculated probability;
- and
- (d) one or more of:
- (i) administering the treatment regimen to a subject classified as a responder, (ii) maintaining the treatment regimen to a subject classified as a responder, (iii) increasing the dose of the treatment in subject exhibiting a mild or poor response, or (iv) ceasing the treatment regimen for a subject classified as a non-responder or poor responder.
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A kit for determining the efficacy of a treatment regimen in a subject suffering from a skin disease, the kit comprises (i) one or more wells configured to hold one or more skin samples and/or a substrate material for collecting at least one skin sample from the subject, wherein said substrate material is inert and essentially free of oxidation and/or reduction characteristics and (ii) means to determine the expression of at least one biomarker in said skin sample and/or the at least one physical measure and optionally instructions of collecting at least one skin sample from a subject and characterizing at least one biomarker in said at least one skin sample of said subject.
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A method for collecting at least one skin sample from a subject, the method comprising contacting at least one skin region in said subject with a substrate material, wherein said substrate material is inert and is essentially free of oxidation and/or reduction characteristics;
- and wherein said skin sample is suitable for characterizing at least one biomarker in said at least one skin sample of said subject.
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Dependencies are inferred from the claim text.