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US 2026/0219280 A1Published application
Methods for Detecting Post-Infectious Irritable Bowel Syndrome
AssigneeCedars-Sinai Medical Center
InventorsMark Pimentel, Christopher Chang
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Abstract
Described herein are methods and systems for detecting and/or distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-CdtB antibodies and/or anti-vinculin antibodies to detect IBS, distinguish IBS from IBD and/or celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.
Claims15
A method of detecting the presence or absence of an antibody capable of binding specifically to vinculin or a fragment thereof, comprising:
- obtaining a biological sample from a subject having a symptom of post-infectious irritable bowel syndrome (PI-IBS);
- and
- detecting the presence or absence of the antibody capable of binding specifically to vinculin or a fragment thereof by contacting vinculin or the fragment thereof to the biological sample, and detecting a signal that indicates the presence of the antibody capable of binding to vinculin or a fragment thereof.
An assay, comprising:
- a biological sample from a subject having a symptom of post-infectious irritable bowel syndrome (PI-IBS);
- and
- an enzyme-linked immunosorbent assay (ELISA) comprising vinculin or a fragment thereof.
Dependencies are inferred from the claim text.