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AssigneePrantae Solutions Private Limited
InventorsSumona Karjee Mishra, Aseem Mishra
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The present invention describes the synthesis of a novel self-assembled organic nanosensor. The self-assembled organic nanosensor is naphthalene sulphonate backbone with a size distribution of 40-2000 nanometers. The self-assembled organic nanosensor exhibits very low auto-fluorescence however, it exhibits high fluorescence activity in presence of albumin protein therefore, the signal is to noise ratio will be high. The fluorescence generated is directly proportional to the concentration of the albumin protein and can be used for quantification of the albumin in sample. The self-assembled organic nanosensor can quantify 0.1 mg/L-3500 mg/L range of albumin concentration linearly. The nanosensor exhibits fluorescence between 5 to 10 seconds of introduction of self-assembled organic nanosensor to the sample containing albumin. The interaction with self-assembled organic nanosensor exhibits the stability to the albumin protein for 20 days in aqueous solution and is stable between −80 degree to +95 degree Celsius.
1-10. (canceled)
A method for synthesizing a self-assembled organic nanosensor for albumin protein detection, the method comprising:
The method as claimed in 11, wherein size of the self-assembled organic nanosensor ranges from 40 nanometer to 2000 nanometer.
The method as claimed in 11, wherein the self-assembled organic nanosensor is stable in aqueous solution at a temperature ranging from minus 80 degree Celsius to 95 degree Celsius.
The method as claimed in 11 wherein the self-assembled organic nanosensor is stable in presence of the albumin protein and does not disassemble wherein the albumin to self-assembled organic nanosensor acts in plurality binding mode with albumin to monomeric backbone.
The method as claimed in 11 wherein the self-assembled organic nanosensor stabilizes the albumin protein in aqueous solution for 20 days at 27 degree Celsius.
The method as claimed in 11, wherein the self-assembled organic nanosensor exhibits a single low auto-fluorescence emission in aqueous solution with peak maxima between 525-545 nm wavelength and high fluorescence between 460-520 nm wavelength with the albumin protein.
A self-assembled organic nanosensor having the molecular structure
A kit comprising a self-assembled organic nanosensor having the molecular structure:
Dependencies are inferred from the claim text.