Methods for diagnosing or monitoring a disease in a subject using spectroscopy

Abstract

A method for diagnosing a disease, such as breast cancer, in a biological sample using spectroscopic data is described. The method involves a computer-implemented method that converts spectroscopic vibrational from the sample into a profile and scores the profile using a pair of reference profiles. Based on the score and a threshold, it can be determined whether the subject from which the sample was obtained has a disease, and, if so, to what extent. The method also allows detection of early and pre-disease states in subjects based on the detection of the signal of low concentration analytes that are indicative of early or incipient disease states. The method is non-invasive, non-subjective, highly specific, and sensitive. The method affords the application of a single standard of diagnostic accuracy, independent of the availability of expert pathologists.

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