Apparatus and system for microfluidic tissue staining
OwnerJoseph Huanginventor
Life of this patent
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Abstract
An apparatus and system for staining tissue samples on slides are disclosed. The apparatus includes a support cartridge, a rotatable cover, and a sealing structure that form a reaction chamber over a tissue section when closed against a slide. Reagents are delivered through internal channels via inlet, outlet, and ventilation ports to enable controlled flow. Temperature and drainage structures may improve staining reliability. Multiple apparatuses may be arranged on a support platform for parallel staining using independent protocols. A transparent layer serves as an optical window, allowing observation or imaging of stained tissue sections without removing the slide.
Claims24
An apparatus for staining a tissue sample disposed on a microscope slide, comprising:
- a support cartridge;
- a rotatable cover mounted to the support cartridge by a hinge;
- a recess formed in the support cartridge and configured to receive the microscope slide;
- a sealing ring or gasket positioned on the support cartridge surrounding the recess;
- wherein a surface of the support cartridge, the sealing ring, and the microscope slide cooperatively define a microfluidic reaction chamber when the rotatable cover is in a closed position;
- an inlet port and a ventilation port in fluid communication with the microfluidic reaction chamber;
- and
- a fluid delivery interface configured to introduce a staining reagent into the microfluidic reaction chamber through the inlet port.
Dependencies are inferred from the claim text.