Method of Predicting Breast Cancer Recurrence
AssigneeUniversity of Cincinnati
InventorsSusan E. Waltz, James Davis, Susanne Wells, Sara Vicente-Munoz
Life of this patent
Estimating the term…
Abstract
A method for predicting tumor recurrence in a subject diagnosed with cancer is provided. The method involves analyzing a tumor sample obtained from the subject by using an assay to determine the extent of expression of one or more genes selected from a first group in the tumor sample (“Group 1 genes”) and a second group in the tumor sample (“Group 2 genes”). An increased likelihood that the subject will exhibit tumor recurrence is predicted when one or more of the Group 1 genes are upregulated, one or more of the Group 2 genes are downregulated or a combination of Group 1 genes are upregulated and Group 2 genes are downregulated.
Claims13
A method for predicting tumor recurrence in a subject diagnosed with cancer, said method comprising:
- a. analyzing a tumor sample obtained from said subject by using an assay to determine the extent of expression of one or more genes selected from the group consisting of ACOT7, ACOT13, ME1, ANGPTL4, DHCR7, SRD5A1, HSD17B2, UGT8, LCLAT1, PLAAT1, DGAT2, ARSK and NEU4 in said tumor sample (“Group 1 genes”);
- b. analyzing the tumor sample by using an assay to determine the extent of expression of one or more genes selected from the group consisting of OLAH, ACACB, IVD, FASN, ACSL6, ELOVL5, CPT1C, CPT1B, ACADSB, ACAA2, ACOX1, PTGR1, FAAH, ACSF, BDH2, ACOT11, MBOAT1, MVK, STARD3, OSBPL5, NCOA1, AGPAT3, AGPAT5, GPAT4, INPP4B, ETNK1, PLAAT5, PITPNM2, SLC44A4, APOA5, GPAT2, MGLL and PLD6 in said tumor sample (“Group 2 genes”);
- and
- c. predicting an increased likelihood that said subject will exhibit tumor recurrence when one or more of the Group 1 genes are upregulated, one or more of the Group 2 genes are downregulated or a combination of Group 1 genes are upregulated and Group 2 genes are downregulated.
Dependencies are inferred from the claim text.