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US 2026/0218307 A1Published application
Diagnosis of skin conditions in veterinary and human patients
AssigneesUniversity of Massachusetts, Trustees of Tufts College
InventorsJillian M. RICHMOND, Jadesola OLAYINKA, Ramon M. ALMELA
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Abstract
Described herein are methods for diagnosing and treating mycosis fungoides (MF) and cutaneous T cell lymphoma (CTCL), e.g., for making a differential diagnosis of CTCL/MF versus other skin conditions.
Claims14
A method comprising:
- obtaining a sample comprising skin from a subject, and
- determining a level of expression of one, two, three, or all four of cathepsin W (CTSW), T Cell Receptor Associated Transmembrane Adaptor 1 (TRAT1), killer cell lectin like receptor K1 (KLRK1;
- also known as NKG2D), and/or XCL1/XCL2 (lymphotactin) in the sample.
A method of diagnosing a subject as having cutaneous T cell lymphoma, the method comprising:
- obtaining a sample comprising skin from a subject;
- determining a level of expression of one, two, three, or all four of cathepsin W (CTSW), T Cell Receptor Associated Transmembrane Adaptor 1 (TRAT1), and killer cell lectin like receptor K1 (KLRK1), and/or XCL1/XCL2 (lymphotactin) in the sample;
- comparing the level of expression of CTSW, TRAT1, and/or KLRK1 in the sample to a reference level, and identifying the subject as having CTCL wherein a level of expression of CTSW, TRAT1, and/or KLRK1 above the reference level indicates that the subject.
A kit comprising reagents for detecting the biomarkers comprising or consisting of two, three, or all four of CTSW, KLRK1, TRAT1 and/or XCL1/XCL2, and optionally one or more controls.
Dependencies are inferred from the claim text.