Diagnosing upper gi pathologies
AssigneeSheba Impact Ltd.
InventorsBella UNGAR, Shomron Silan BEN-HORIN, Ella FUDIM
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Abstract
Methods of diagnosing upper gastrointestinal pathologies are provided. Accordingly, there are provided methods of isolating an RNA sample from an upper gastrointestinal tract of a human subject. Also provided are methods of diagnosing an upper gastrointestinal pathology comprising analyzing an expression level of at least one gene associated with the pathology in a sample of an upper gastrointestinal tract secretion of the subject.
Claims13
A method of diagnosing and treating celiac in a human subject in need thereof, the method comprising:
- (i) receiving an identification that a subject has celiac according to a method comprising:
- (a) analyzing an expression level of at least one gene selected from the group consisting of AP006216.3, AC011754.1, CCDC152, AKR7A3 and IGLV2-14 in a sample of an upper GI tract secretion of the subject, wherein said expression level above a predetermined threshold is indicative of celiac;
- and/or
- (b) analyzing an expression level of at least one gene selected from the group consisting of AC122718.1, AP001011.1, MICB-DT, RN7SL288P and AC092746.1 in a sample of an upper GI tract secretion of the subject, wherein said expression level below a predetermined threshold is indicative of celiac;
- and
- (ii) administering to the subject a therapeutically effective amount of an agent useful for treating celiac.
A diagnostic kit for diagnosing celiac, the kit comprising at least two agents capable of specifically detecting expression products of at least two genes associated with celiac, wherein at least one of said at least two genes is selected from the group consisting of AC122718.1, AP001011.1, MICB-DT, RN7SL288P, AC092746.1, AP006216.3, AC011754.1, CCDC152, AKR7A3 and IGLV2-1.
Dependencies are inferred from the claim text.