Device for detecting a target nucleic acid sequence
AssigneeUniversiteit Twente
InventorsJeanne Elisabeth VAN DONGEN, Jan Cornelis Titus EIJKEL, Jurriaan HÜSKENS, Loes Irene SEGERINK
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Abstract
The present invention relates to device for detecting at least one target nucleic acid sequence. The device comprises a surface which carries at least one activatable protein which is activated in the presence of the at least one target nucleic acid sequence; one or more reporter constructs which provide a detectable signal upon activation of the activatable protein, wherein the at least one activatable protein and/or the one or more reporter constructs are immobilized, optionally via a linker, to one or more moieties capable of moving along the surface.
Claims19
A device for detecting at least one target nucleic acid sequence, wherein the device comprises a surface which carries
- at least one activatable protein which is activated in the presence of the at least one target nucleic acid sequence;
- one or more reporter constructs which provide a detectable signal upon activation of the activatable protein,
- wherein the at least one activatable protein and/or the one or more reporter constructs are immobilized, optionally via a linker, to one or more moieties capable of moving along the surface.
A method for detecting at least one target nucleic acid sequence, the method comprising
- i. applying a liquid sample comprising the at least one target nucleic acid sequence to the surface of the device according to any one of the previous claims;
- and
- ii. detecting activation of the activatable protein, preferably by measuring the detectable signal provided by one or more reporter constructs.
(canceled)
Dependencies are inferred from the claim text.