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US 2026/0218253 A1Published application
Fermentative production guanidinoacetic acid (gaa) from serine by attenuating l serine ammonia lyase activity in microorganisms
AssigneeEvonik Operations GmbH
InventorsSteffen Schaffer, Martina Carrillo Camacho, Frank Schneider, Mirja Wessel
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Abstract
A microorganism has been modified to express genes encoding proteins having arginine:glycine amidinotransferase (AGAT) activity as well as modified to increase the production of glycine from L-serine and a method produces guanidinoacetic acid (GAA) through the fermentation of such microorganism and a method produces creatine.
Claims12
A microorganism, comprising:
- at least one heterologous gene coding for a protein having the function of a L-arginine:glycine amidinotransferase, and
- wherein
- a gene encoding a protein having the function of a L-serine ammonia lyase is inactivated or deleted.
Dependencies are inferred from the claim text.