Back to results
US 2026/0218252 A1Published application
Improved enzyme-assisted synthesis of chlorhexidine base
AssigneeXttrium Laboratories, Inc.
InventorsPrajakta Dandekar Jain, Ratnesh Jain, Lalit Khare
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a method for preparing chlorhexidine, salts thereof, or hydrates thereof, wherein the method comprises an enzymatic chlorination, a coupling step, or a combination thereof. The disclosure further includes compositions comprising chlorhexidine prepared by the disclosed methods.
Claims25
A method of preparing the compound of formula (II),
- a salt thereof, or hydrate thereof;
- the method comprising enzymatic chlorination of formula (I):
- or a salt thereof;
- wherein the chlorination is carried out with chloroperoxidase (CPO), at least one chloride donor, at least one oxidant, and a buffer solution.
1 more element
A method of preparing chlorhexidine, a salt thereof, or a hydrate thereof, comprising combining a compound of formula (II):
- a salt thereof, or a hydrate thereof, with a compound of formula (IV):
- in further combination with one or more base, and wherein X is a leaving group.
A method of preparing chlorhexidine comprising, the enzymatic chlorination of formula (I):
- or a salt thereof, to form formula (II):
- a salt thereof, or a hydrate thereof;
- the enzymatic chlorination comprising chloroperoxidase (CPO), at least one chloride donor, at least one oxidant, and a buffer solution;
- wherein the enzymatic chlorination is followed by coupling formula (II), a salt thereof, or a hydrate thereof, with a compound of formula (IV):
- the coupling further comprising one or more base, and wherein X is a leaving group.
2 more elements
Dependencies are inferred from the claim text.