Engineered bacteria for cellular barrier maintenance and protection
AssigneeThe Trustees of Columbia University in the City of New York
InventorsHarris He Wang, Carlotta Ronda, Leonie Brockmann, Logan Schwanz
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Abstract
The present disclosure relates to engineering bacteria and methods for promoting barrier function in skin and mucosal surfaces. In particular, the disclosure is related to engineering bacterium to produce a delta hemolysin (delta toxin) peptide and methods of using the engineered bacteria or the delta hemolysin peptide for improving or maintaining gut health, regulating glucose metabolism, maintaining intestinal integrity, decreasing inflammation, modulating wound healing and tissue regeneration, and treating or preventing a disease or disorder.
Claims17
A bacterium engineered for the production of a heterologous delta hemolysin peptide or variant or polypeptide comprising thereof,
- wherein the bacterium comprises a nucleic acid encoding the delta hemolysin peptide or variant or polypeptide comprising thereof.
A method for improving or maintaining gut health, regulating glucose metabolism, maintaining intestinal integrity, and/or promoting tissue repair and regeneration in a subject in need thereof comprising introducing a nucleic acid encoding a delta hemolysin peptide or variant or polypeptide thereof into a bacterium in the subject.
(canceled)
Dependencies are inferred from the claim text.