Modified madariaga viruses, self-replicating rna constructs, and uses thereof
AssigneeReplicate Bioscience, Inc.
InventorsNathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONER
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Abstract
The present disclosure relates to the field of molecular virology, including nucleic acid molecules comprising modified viral genomes or self-replicating RNAs, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting a pharmacodynamic effect in a subject in need thereof, as well as methods for preventing and/or treating various health conditions.
Claims58
A nucleic acid construct comprising a nucleic acid sequence encoding a modified Madariaga virus (MADV) genome or self-replicating RNA (srRNA), wherein the modified MADV genome or srRNA is devoid of at least a portion of the nucleic acid sequence encoding one or more viral structural proteins.
Dependencies are inferred from the claim text.