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US 2026/0218148 A1Published application
Compositions and methods relating to epigenetic modulation
AssigneeDuke University
InventorsBoris Kantor, Ornit Chiba-Falek
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Abstract
Disclosed herein are methods of effecting precision epigenetic modulation of one or more genes of interest. Disclosed herein are isolated nucleic acid molecules, viral vectors, rAAV vectors, pharmaceutical formulations, host cells, guide RNAs, and plasmids for use in the disclosed methods.
Claims42
An isolated nucleic acid molecule, comprising:
- a nucleic acid sequence encoding (i) a deactivated Cas9 (dCas9) endonuclease, (ii) at least one polypeptide having an enzymatic activity, and (iii) at least one guide RNA targeting a gene of interest or portion thereof.
Dependencies are inferred from the claim text.