Polysaccharide-based macromolecule cross-linking agent, polysaccharide-based biological material, and preparation method therefor and use thereof

Abstract

This invention provides polysaccharide-based polymer crosslinkers, polysaccharide-based biomaterials with their preparation methods and applications. The polysaccharide-based polymer crosslinker in this invention is a polysaccharide-based polymer crosslinker modified with o-phthalaldehyde group, which does not rely on synthetic hydrophilic polymer skeleton and complicated chemical synthesis steps. This polysaccharide-based polymer crosslinker and a water-soluble small molecule or polymer containing one or more of primary amine, hydrazine, hydrazide, hydroxylamine, or sulfhydryl group in an aqueous medium together constitute a polysaccharide-based dual-component hydrogel material, which has the advantages of injectability, low swelling, and strong tissue adhesion. In addition, this polysaccharide-based dual-component hydrogel material can be further prepared into polysaccharide-based biomaterials in the form of membranes, powders and sponges, etc., which can be used as tissue adhesives, sealants, hemostatic agents, tissue engineering materials, etc., and which have a wide range of biomedical application prospects.

Dependencies are inferred from the claim text.