Igg fc variants with reduced self-association
AssigneeThe Regents of the University of Michigan
InventorsMatthew D. Smith, Peter M. Tessier, Na-Young Kwon, Emily Makowski
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Abstract
The present disclosure provides polypeptides comprising variant IgG Fc regions, particularly variants which reduced self-association, and compositions and methods of using the polypeptides.
Claims27
A polypeptide comprising a variant IgG Fc region comprising one or more amino acid substitutions at positions selected from 355, 362, 382, 390, 419, and 443, in reference to a wild-type or parent IgG Fc region sequence and numbered according to the EU numbering system.
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A method of decreasing the self-association of a polypeptide comprising an IgG Fc region comprising introducing one or more amino acid substitutions in the IgG Fc region at positions selected from 355, 362, 382, 390, 419, 443, in reference to a wild-type IgG Fc and numbered according to the EU numbering system or substituting the IgG Fc region with a variant IgG Fc region comprising one or more amino acid substitutions at positions selected from 355, 362, 382, 390, 419, 443, in reference to a wild-type IgG Fc and numbered according to the EU numbering system.
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Dependencies are inferred from the claim text.