Antibodies targeting steap-1 and uses thereof
AssigneeJanux Therapeutics, Inc.
InventorsDavid CAMPBELL, Thomas R. DIRAIMONDO, John LAUDENSLAGER
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Abstract
Disclosed herein are polypeptides or polypeptide complexes comprising an antibody or antigen binding fragment thereof that binds to six-transmembrane epithelial antigen of the prostate-1 (STEAP-1).
Claims103
A polypeptide or polypeptide complex comprising an antibody or antigen binding fragment thereof that binds to six-transmembrane epithelial antigen of the prostate-1 (STEAP-1), wherein the antibody or antigen binding fragment thereof comprises an immunoglobulin light chain and an immunoglobulin heavy chain and comprises at least one amino acid mutation wherein the at least one amino acid mutation is selected from a position corresponding to V24, Y27, W35, G45, T58, L64, S66, T74, E99, and M111 of SEQ ID NO:
- 61 and Q3, S9, S12, A13, V15, D17, V19, T22, Q35, K48, A49, S66, P86, F89, T91, and Q106 of SEQ ID NO:
- 62.
A polypeptide or polypeptide complex comprising an antibody or antigen binding fragment thereof that binds to six-transmembrane epithelial antigen of the prostate-1 (STEAP-1), wherein the antibody or antigen binding fragment thereof comprises an immunoglobulin light chain and an immunoglobulin heavy chain wherein the immunoglobulin heavy chain and the immunoglobulin light chain comprise a set of six CDR sequences selected from the group consisting of:
- CDR1-H:
- SEQ ID NO:
- 4, CDR2-H:
- SEQ ID NO:
- 10, CDR3-H:
- SEQ ID NO:
- 16,
- CDR1-L:
- SEQ ID NO:
- 22, CDR2-L:
- SEQ ID NO:
- 28, CDR3-L:
- SEQ ID NO:
- 34;
- CDR1-H:
- SEQ ID NO:
- 5, CDR2-H:
- SEQ ID NO:
- 11, CDR3-H:
- SEQ ID NO:
- 17,
- CDR1-L:
- SEQ ID NO:
- 23, CDR2-L:
- SEQ ID NO:
- 29, CDR3-L:
- SEQ ID NO:
- 35;
- CDR1-H:
- SEQ ID NO:
- 6, CDR2-H:
- SEQ ID NO:
- 12, CDR3-H:
- SEQ ID NO:
- 18,
- CDR1-L:
- SEQ ID NO:
- 24, CDR2-L:
- SEQ ID NO:
- 30, CDR3-L:
- SEQ ID NO:
- 36;
- CDR1-H:
- SEQ ID NO:
- 7, CDR2-H:
- SEQ ID NO:
- 13, CDR3-H:
- SEQ ID NO:
- 19,
- CDR1-L:
- SEQ ID NO:
- 25, CDR2-L:
- SEQ ID NO:
- 31, CDR3-L:
- SEQ ID NO:
- 37;
- and
- CDR1-H:
- SEQ ID NO:
- 8, CDR2-H:
- SEQ ID NO:
- 14, CDR3-H:
- SEQ ID NO:
- 20,
- CDR1-L:
- SEQ ID NO:
- 26, CDR2-L:
- SEQ ID NO:
- 32, CDR3-L:
- SEQ ID NO:
- 38.
Dependencies are inferred from the claim text.