Nucleic acid molecule encoding a car and a vector including the same, a car, an immune cell including the car and a pharmaceutical composition including the cell, and a method for producing an immune cell including the car

A nucleic acid molecule comprising a nucleotide sequence encoding a chimeric antigen receptor, wherein

• the nucleic acid molecule comprises a segment encoding an extracellular domain, a segment encoding a transmembrane domain, and a segment encoding an intracellular domain,
• the segment encoding the extracellular domain comprises a nucleotide sequence encoding an antigen binding region comprising a light chain variable region and a heavy chain variable region, and
• at least three codons in the nucleotide sequence encoding framework region 3 of the light chain variable region defined by the Kabat method are codons encoding basic amino acid residues.