Antibodies specific to transmembrane and coiled-coil domain family 3 and uses thereof
AssigneesDevelopment Center for Biotechnology, Chang Gung Memorial Hospital, Linkou
InventorsCheng-Chou Yu, Shao-Wei Huang, Chuan-Lung Hsu, Alice L. Yu, John Yu, Ya-Hui Wang
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Abstract
The present disclosure relates to an antibody or antigen-binding fragment thereof that is specific for transmembrane and coiled-coil domain family 3 (TMCC3). The present disclosure also relates to a pharmaceutical composition for treating and/or preventing a disease related to a TMCC3-mediated signal in a subject in need thereof, and a method for detecting TMCC3, a cancer stem cell or a cancer in a sample.
Claims27
An antibody or antigen-binding fragment thereof that is specific for an epitope in transmembrane and coiled-coil domain family 3 (TMCC3);
- wherein the antibody or antigen-binding fragment thereof comprises complementarity determining regions (CDRs) of a heavy chain variable region and CDRs of a light chain variable region,
- wherein the CDRs of the heavy chain variable region comprise:
- CDRH1 of an amino acid sequence of SEQ ID NO:
- 3, CDRH2 of an amino acid sequence of SEQ ID NO:
- 4, and CDRH3 of an amino acid sequence of SEQ ID NO:
- 5;
- and
- wherein the CDRs of the light chain variable region comprise:
- CDRL1 of an amino acid sequence of SEQ ID NO:
- 6, CDRL2 of an amino acid sequence of SEQ ID NO:
- 7, and CDRL3 of an amino acid sequence of SEQ ID NO:
- 8.
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Dependencies are inferred from the claim text.