Anti-cd26 antibody and use thereof

Abstract

Provided are an antibody or antigen-binding fragment that binds to human CD26, and use thereof in the preparation of a medicament for treating tumors with high CD26 expression. The mouse-derived anti-CD26 antibody and antigen-binding fragment has high specificity, affinity, and binding activity, as well as cytotoxic activity against various tumor cells. Based on this mouse-derived anti-CD26 antibody, humanized bispecific antibodies, full-length humanized antibodies, and antibody-drug conjugates have been successfully constructed. Compared with other antibodies derived from other mouse antibodies, these antibodies demonstrate higher affinity and binding activity to tumor cells, higher internalization levels in tumor cells, and lower internalization levels in non-tumor cells, thereby exhibiting improved efficacy and safety profiles in ADCs.

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