Cd38 monoclonal antibody and use thereof

A method for treatment of an autoimmune disease in a subject comprising administering to the subject a therapeutically effective amount of a monoclonal antibody specifically binding to human CD38, or an antigen binding fragment thereof, wherein the monoclonal antibody comprises three heavy chain complementarity-determining regions HCDR1, HCDR2, and HCDR3, and three light chain complementarity-determining regions LCDR1, LCDR2, and LCDR3, wherein:

• (a) the amino acid sequence of the HCDR1 is set forth in SEQ ID NO:
• 1 or a variant thereof with one to three conservative amino acid substitutions;
• the amino acid sequence of the HCDR2 is set forth in SEQ ID NO:
• 2 or a variant thereof with one to three conservative amino acid substitutions;
• the amino acid sequence of the HCDR3 is set forth in SEQ ID NO:
• 6 or a variant thereof with one to three conservative amino acid substitutions;
• the amino acid sequence of the LCDR1 is set forth in SEQ ID NO:
• 7 or a variant thereof with one to three conservative amino acid substitutions;
• the amino acid sequence of the LCDR2 is set forth in SEQ ID NO:
• 9 or a variant thereof with one to three conservative amino acid substitutions;
• and the amino acid sequence of the LCDR3 is set forth in SEQ ID NO:
• 11 or a variant thereof with one to three conservative amino acid substitutions;
• (b) the amino acid sequence of the HCDR1 is set forth in SEQ ID NO:
• 1;
• the amino acid sequence of the HCDR2 is set forth in SEQ ID NO:
• 2, SEQ ID NO:
• 3, SEQ ID NO:
• 4, or SEQ ID NO:
• 5;
• the amino acid sequence of the HCDR3 is set forth in SEQ ID NO:
• 6;
• the amino acid sequence of the LCDR1 is set forth in SEQ ID NO:
• 7 or SEQ ID NO:
• 8;
• the amino acid sequence of the LCDR2 is set forth in SEQ ID NO:
• 9 or SEQ ID NO:
• 10;
• and the amino acid sequence of the LCDR3 is set forth in SEQ ID NO:
• 11;
• (c) the amino acid sequence of the HCDR1 is set forth in SEQ ID NO:
• 1;
• the amino acid sequence of the HCDR2 is set forth in SEQ ID NO:
• 2;
• the amino acid sequence of the HCDR3 is set forth in SEQ ID NO:
• 6;
• the amino acid sequence of the LCDR 1 is set forth in SEQ ID NO:
• 7;
• the amino acid sequence of the LCDR2 is set forth in SEQ ID NO:
• 9;
• and the amino acid sequence of the LCDR3 is set forth in SEQ ID NO:
• 11;
• or
• (d) the amino acid sequence of the HCDR1 is set forth in SEQ ID NO:
• 1;
• the amino acid sequence of the HCDR2 is set forth in SEQ ID NO:
• 2;
• the amino acid sequence of the HCDR3 is set forth in SEQ ID NO:
• 6;
• the amino acid sequence of the LCDR1 is set forth in SEQ ID NO:
• 8;
• the amino acid sequence of the LCDR2 is set forth in SEQ ID NO:
• 10;
• and the amino acid sequence of the LCDR3 is set forth in SEQ ID NO:
• 11.