Antibodies that bind ox40l and methods of use
AssigneeApogee Therapeutics, Inc.
InventorsByong Ha KANG, Eric Franklin ZHU, Hussam Hisham SHAHEEN, Jason Zee Seug OH, Mohammad Murshid ALAM
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Abstract
Described herein are novel and improved antibodies that bind OX40L and methods of use thereof. In certain aspects, described herein are methods of inhibiting OX40L biological activity. In certain aspects, described herein are pharmaceutical compositions comprising the anti-OX40L antibodies. In certain aspects, the antibodies and methods described herein are used for treatment of an inflammatory disease or disorder associated with elevated levels of OX40L.
Claims31
1-262. (canceled)
An isolated antibody that binds OX40L, wherein the antibody comprises:
- a CDR-H1 comprising the sequence set forth in SEQ ID NO:
- 1;
- a CDR-H2 comprising the sequence set forth in SEQ ID NO:
- 70;
- a CDR-H3 comprising the sequence set forth in SEQ ID NO:
- 175;
- a CDR-L1 comprising the sequence set forth in SEQ ID NO:
- 258;
- a CDR-L2 comprising the sequence set forth in SEQ ID NO:
- 335;
- and
- a CDR-L3 comprising the sequence set forth in SEQ ID NO:
- 368.
An isolated antibody that binds OX40L, wherein the antibody comprises:
- a CDR-H1 comprising the sequence set forth in SEQ ID NO:
- 1;
- a CDR-H2 comprising the sequence set forth in SEQ ID NO:
- 70;
- a CDR-H3 comprising the sequence set forth in SEQ ID NO:
- 175;
- a CDR-L1 comprising the sequence set forth in SEQ ID NO:
- 258;
- a CDR-L2 comprising the sequence set forth in SEQ ID NO:
- 335;
- and
- a CDR-L3 comprising the sequence set forth in SEQ ID NO:
- 368;
- and wherein the antibody comprises a human IgG1 Fc region with LALA and/or YTE mutations.
An isolated antibody that binds OX40L, wherein the antibody comprises a heavy chain variable region sequence set forth in SEQ ID NO:
- 419, a light chain variable region sequence set forth in SEQ ID NO:
- 489, a constant heavy chain sequence set forth in SEQ ID NO:
- 651, and a constant light chain sequence set forth in SEQ ID NO:
- 738.
An isolated antibody that binds OX40L, wherein the antibody comprises a heavy chain variable region sequence set forth in SEQ ID NO:
- 419 and a light chain variable region sequence set forth in SEQ ID NO:
- 489, wherein the antibody comprises a human IgG1 Fc region with LALA and/or YTE mutations.
Dependencies are inferred from the claim text.