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US 2026/0217837 A1Published application
Fgfr3 binding molecules and methods of use thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsYan YANG, Naga Suhasini AVVARU, Christopher DALY, Yang SHEN, Chia-Yang LIN
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Abstract
The present disclosure relates to molecules capable of binding to FGFR3 and methods of use thereof.
Claims50
A multispecific binding molecule (MBM), the MBM comprising:
- (a) an antigen-binding domain 1 (ABD1) that specifically binds to a first epitope of FGFR3;
- and
- (b) an antigen-binding domain 2 (ABD2) that specifically binds to a second epitope of FGFR3 that is different from the first epitope.
A multispecific binding molecule (MBM) comprising:
- (a) a first polypeptide chain comprising, in an N- to C-terminal orientation, (i) a first scFv that specifically binds to a first epitope of FGFR3, operably linked to (ii) a first heavy chain region of a first Fab that specifically binds to a second epitope of FGFR3 that is different from the first epitope, operably linked to (iii) an Fc domain;
- (b) a second polypeptide chain comprising, in an N- to C-terminal orientation, (i) a second scFv that specifically binds to the first epitope, operably linked to (ii) a second heavy chain region of a second Fab that specifically binds to the second epitope, operably linked to (iii) an Fc domain;
- (c) a third polypeptide chain comprising a first light chain that pairs with the first heavy chain region to form the first Fab;
- (d) a fourth polypeptide chain comprising a second light chain that pairs with the second heavy chain region to form the second Fab.
1 more element
A multispecific binding molecule (MBM) comprising:
- (a) a first polypeptide chain comprising, in an N- to C-terminal orientation, (i) a first heavy chain region of a first Fab that specifically binds to a first epitope of FGFR3, operably linked to (ii) a second heavy chain region of a second Fab that specifically binds to a second epitope of FGFR3 that is different from the first epitope, operably linked to (iii) an Fc domain;
- (b) a second polypeptide chain comprising, in an N- to C-terminal orientation, (i) a third heavy chain region of a third Fab that specifically binds to the first epitope, operably linked to (ii) a fourth heavy chain region of a fourth Fab that specifically binds to the second epitope, operably linked to (iii) an Fc domain;
- (c) a third polypeptide chain comprising a first light chain that pairs with the first heavy chain region to form the first Fab;
- (d) a fourth polypeptide chain comprising a second light chain that pairs with the second heavy chain region to form the second Fab.
- (e) a fifth polypeptide chain comprising a third light chain that pairs with the third heavy chain region to form the third Fab.
- (f) a sixth polypeptide chain comprising a fourth light chain that pairs with the fourth heavy chain region to form the fourth Fab.
3 more elements
Dependencies are inferred from the claim text.