Bispecific antibodies targeting cd117 and cd3
OwnerSj ERKELAND, Pd KATSIKIS +2inventors
InventorsSj ERKELAND, Pd KATSIKIS, Yun HE, Yuandong WANG
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Abstract
Provided herein are bispecific antibodies comprising a first antigen binding region and a second antigen binding region, wherein the first antigen binding region binds to CD117 and comprises a first heavy chain variable region and a first light chain variable region, and the second binding region binds to CD3 and comprises a second heavy chain variable region and a second light chain variable region. Also provided are compositions comprising the bispecific antibodies as well as uses of the bispecific antibodies and compositions.
Claims23
A bispecific antibody or an antigen binding fragment thereof, comprising a first antigen binding region and a second antigen binding region, wherein the first antigen binding region binds to CD117 and comprises a first heavy chain variable region (VH_A) and a first light chain variable region (VL_A), and the second binding region binds to CD3 and comprises a second heavy chain variable region (VH_B) and a second light chain variable region (VL_B), wherein:
- the VH_A comprises a HCDR1, a HCDR2 and a HCDR3 of a VH comprising the amino acid sequence of SEQ ID NO:
- 44;
- the VL_A comprises a LCDR1, a LCDR2 and a LCDR3 of a VL comprising the amino acid sequence of SEQ ID NO:
- 47;
- the VH_B comprises a HCDR1, a HCDR2 and a HCDR3 of a VH comprising the amino acid sequence of SEQ ID NO:
- 43;
- and
- the VL_B comprises a LCDR1, a LCDR2 and a LCDR3 of a VL comprising the amino acid sequence of SEQ ID NO:
- 46.
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Dependencies are inferred from the claim text.