Monoclonal antibody specifically binding to claudin-18.2 and use thereof

A monoclonal antibody specifically binding to claudin-18.2 (claudin-18 spliced variant 2, CLDN18.2) selected from the group consisting of:

• (a) a monoclonal antibody specifically binding to claudin-18.2 comprising a heavy chain variable region containing heavy chain CDR (complementarity-determining region) 1 as described in SEQ ID NO:
• 1, heavy chain CDR2 as described in SEQ ID NO:
• 2, and heavy chain CDR3 as described in SEQ ID NO:
• 3, and a light chain variable region containing light chain CDR1 as described in SEQ ID NO:
• 5, light chain CDR2 consisting of the amino acid sequence DVS, and light chain CDR3 as described in SEQ ID NO:
• 6,
• (b) a monoclonal antibody specifically binding to claudin-18.2, comprising a heavy chain variable region containing heavy chain CDR1 as described in SEQ ID NO:
• 1, heavy chain CDR2 as described in SEQ ID NO:
• 2, and heavy chain CDR3 as described in SEQ ID NO:
• 8, and a light chain variable region containing light chain CDR1 as described in SEQ ID NO:
• 10, light chain CDR2 consisting of the amino acid sequence AAS, and light chain CDR3 as described in SEQ ID NO:
• 11, and
• (c) a monoclonal antibody specifically binding to claudin-18.2, comprising a heavy chain variable region containing heavy chain CDR1 as described in SEQ ID NO:
• 1, heavy chain CDR2 as described in SEQ ID NO:
• 2, and heavy chain CDR3 as described in SEQ ID NO:
• 13, and a light chain variable region containing light chain CDR1 as described in SEQ ID NO:
• 15, light chain CDR2 consisting of the amino acid sequence GAF, and light chain CDR3 as described in SEQ ID NO:
• 11,
• or an antigen-binding fragment thereof.