Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof

An antibody having a binding specificity for human IL-17A, wherein the antibody comprises (i) HCDR1, HCDR2, and HCDR3 sequences of SEQ ID NOs:

• 1, 2, and 3, respectively, and LCDR1, LCDR2, and LCDR3 sequences of SEQ ID NOs:
• 12, 13, and 14, respectively, and wherein the VH comprises an amino acid sequence that is in the framework regions at least 90 percent identical to the amino acid sequence SEQ ID NO:
• 10;
• and the VL comprises an amino acid sequence that is in the framework regions at least 90 percent identical to the amino acid sequence SEQ ID NO:
• 21;
• or (ii) HCDR1, HCDR2, and HCDR3 sequences of SEQ ID NOs:
• 39, 40, and 41, respectively, and LCDR1, LCDR2, and LCDR3 sequences of SEQ ID NOs:
• 50, 51, and 52, respectively, and wherein the VH comprises an amino acid sequence that is in the framework regions at least 90 percent identical to the amino acid sequence SEQ ID NO:
• 48;
• and the VL comprises an amino acid sequence that is in the framework regions at least 90 percent identical to the amino acid sequence SEQ ID NO:
• 59.