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US 2026/0217805 A1Published application
Alpha-synuclein protofibril-binding antibodies
AssigneeBioArctic AB
InventorsEva Nordström, Jessica Sigvardson, Patrik Nygren
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Abstract
The present disclosure is based, in part, on the discovery of antibodies that selectively targets human α-synuclein aggregates such as oligomers/protofibrils, such as BAN0805. BAN0805 has a lower tendency to bind to the undesired monomeric α-synuclein target as compared to mouse monoclonal antibody mAb47.
Claims15
-25. (canceled)
A method of producing an assembled antibody, comprising the steps of:
- (1) providing one or more vectors, wherein the one or more vectors comprise a first nucleic acid sequence comprising SEQ ID NO:19 and a second nucleic acid sequence comprising SEQ ID NO:
- 20;
- (2) transfecting a host cell with the one or more vectors;
- and
- (3) culturing the host cell under conditions which allow for the secretion of the assembled antibody.
2 more elements
Dependencies are inferred from the claim text.