Anti-hiv antibodies
AssigneeInternational AIDS Vaccine Initiative
InventorsElise LANDAIS, Devin SOK
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to anti-HIV Env antibodies and their use in the treatment or prevention of HIV/AIDS.
Claims35
1-24. (canceled)
An isolated monoclonal antibody that specifically binds to HIV Env and comprises a heavy chain variable region VH) comprising a VH CDR1, VH CDR2, and VH CDR3 and a light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3, wherein
- (a) the VH CDR1 comprises the VH CDR1 of PCIN63-66B, PCIN63-71B, PCIN63-71C, PCIN63-71D2b, PCIN63-71F, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71N1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, PCIN63-77C, or PCIN63-77D;
- (b) the VH CDR2 comprises the VH CDR2 of PCIN63-66B, PCIN63-71B, PCIN63-71C, PCIN63-71D2b, PCIN63-71F, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71N1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, PCIN63-77C, or PCIN63-77D;
- (c) the VH CDR3 comprises the VH CDR3 of PCIN63-66B, PCIN63-71B, PCIN63-71C, PCIN63-71D2b, PCIN63-71F, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71N1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, PCIN63-77C, or PCIN63-77D;
- (d) the VL CDR1 comprises the VL CDR1 of PCIN63-66B, PCIN63-71B, PCIN63-71C, PCIN63-71D2b, PCIN63-71F, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71N1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, PCIN63-77C, or PCIN63-77D;
- (e) the VL CDR2 comprises the VL CDR2 of PCIN63-66B, PCIN63-71B, PCIN63-71C, PCIN63-71D2b, PCIN63-71F, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71N1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, PCIN63-77C, or PCIN63-77D;
- and
- (f) the VL CDR3 comprises the VL CDR3 of PCIN63-66B, PCIN63-71B, PCIN63-71C, PCIN63-71D2b, PCIN63-71F, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71N1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, PCIN63-77C, or PCIN63-77D.
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A method of producing an engineered variant of a PCIN63 antibody comprising
- (a) substituting one or more amino acid residues of the VH;
- and/or substituting one or more amino acid residues of the VL to create an engineered variant antibody, and
- (b) and producing the engineered variant antibody,
- wherein the PCIN63 antibody is
- i. PCIN63-66B, PCIN63-71B, PCIN63-71C, PCIN63-71D2b, PCIN63-71F, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71N1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, PCIN63-77C, or PCIN63-77D;
- ii. PCIN63-66B, PCIN63-71C, PCIN63-71D2b, PCIN63-71G, PCIN63-71H, PCIN63-71I1a, PCIN63-71J2a, PCIN63-71K, PCIN63-71L, PCIN63-71M1a, PCIN63-71O, PCIN63-71P, PCIN63-77B1b, or PCIN63-77C;
- or PCIN63-71I1a, or PCIN63-71L.
Dependencies are inferred from the claim text.