Rna compositions targeting hiv
AssigneeBioNTech SE
InventorsValentin Le Douce, Felix Tolksdorf, Johannes Nelke, Gábor Boros, Jonas Reinholz, Katalin Karikó, Sergey Bessonov
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Abstract
The present disclosure provides compositions (e.g., pharmaceutical compositions) for delivery of anti-HIV antibody agents and related technologies (e.g., components thereof and/or methods relating thereto). Among other things, the present disclosure provides polyribonucleotides encoding an immnunoglobulin chain of an anti-HIV antibody agent.
Claims73
A polyribonucleotide encoding an immunoglobulin chain of an antibody agent, wherein the immunoglobulin chain comprises a single chain fragment variable (scFv), and the scFv comprises a heavy chain variable (VH) domain, a linker, and a light chain variable (VL) domain,
- wherein the VH domain comprises an HCDR1, an HCDR2, and an HCDR3, wherein the HCDR1, HCDR2, and HCDR3 comprise an amino acid sequence according to SEQ ID NO:
- 18, 21, and 24, respectively, and
- wherein the VH domain comprises a first mutation at residue 3 and a second mutation at residue 5 relative to the amino acid sequence according to SEQ ID NO:
- 1494;
- and
- wherein the VL domain comprises an LCDR1, an LCDR2, and an LCDR3, wherein the LCDR1, LCDR2, and LCDR3 comprise an amino acid sequence according to SEQ ID NO:
- 27, 30, and 33, respectively.
A polyribonucleotide comprising or consisting of a ribonucleic acid sequence according to any one of SEQ ID NOs:
- 1000, 1048, 1096, or 1044.
Dependencies are inferred from the claim text.