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US 2026/0217798 A1Published application
Formulations of anti-rsv antibodies and methods of use thereof
AssigneeMerck Sharp & Dohme Corp.
InventorsVenus Hashemi, Arnab De, Chakravarthy Nachu Narasimhan
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Abstract
The present invention relates to stable formulations comprising antibodies or antigen-binding fragments thereof that bind to respiratory syncytial virus (RSV). Also provided are methods of preventing and/or treating RSV-related diseases with the formulations of the invention.
Claims24
An anti-RSV antibody formulation comprising:
- a) about 50 mg/mL to about 250 mg/mL of an anti-RSV antibody, or antigen-binding fragment thereof,
- b) about 5 mM to about 20 mM histidine;
- c) about 4% to about 8% (w/v) sucrose;
- d) an excipient selected from the group consisting of
- about 25 mM to about 75 mM of L-arginine or a pharmaceutically acceptable salt of L-arginine,
- about 25 mM to about 75 mM of L-lysine or a pharmaceutically acceptable salt of L-lysine,
- a mixture of about 25 mM to about 75 mM L-arginine or a pharmaceutically acceptable salt of L-arginine and about 25 mM to about 75 mM L-glutamate or a pharmaceutically acceptable salt of L-glutamate, and
- a mixture of about 25 mM to about 75 mM of L-arginine or a pharmaceutically acceptable salt of L-arginine and about 25 mM to about 75 mM L-lysine or a pharmaceutically acceptable salt of L-lysine;
- and
- e) about 0.01% to about 0.10% (w/v) polysorbate 80.
7 more elements
Dependencies are inferred from the claim text.