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US 2026/0217791 A1Published application
Agents and methods for treating complement diseases
AssigneeComplement Therapeutics Limited
InventorsSimon J. Clark, Mustafa Munye, Sonika Rathi
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Abstract
Polypeptide and nucleic acid agents for treating diseases and conditions associated with complement are disclosed. Also disclosed are expression vectors, compositions and cells comprising the agents, and methods using the agents, e.g. for treatment.
Claims44
A polynucleotide comprising, in 5′ to 3′ or 3′ to 5′ order:
- (i) a first nucleotide sequence comprising a promoter;
- (ii) a second nucleotide sequence operably linked to the first nucleotide sequence, the second nucleotide sequence comprising a transgene, and wherein the transgene comprises or consists of a nucleotide sequence having at least 80% sequence identity to SEQ ID NO:6 or 5;
- and
- (iii) a polyadenylation signal sequence.
1 more element
Dependencies are inferred from the claim text.