Cxcr3 ligand
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsYohei YAMAMOTO, Mika SAKURAI, Kenta HARAYA
Life of this patent
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Abstract
The present disclosure relates to CXCR3 ligands having resistance to DPPIV and having CXCR3-expressing cell migration-inducing activity. The present disclosure specifically relates to N-terminal amino acid modifications and N-terminal amino acid sequences important for resistance to DPPIV and CXCR3-expressing cell migration-inducing activity.
Claims14
A method of producing a CXCR3 ligand having resistance to DPPIV, wherein the method comprises modifying a parent CXCR3 ligand in which the 2nd amino acid from the N-terminus is P or A, wherein the method comprises at least one of the following:
- (1) substituting the 2nd amino acid from the N-terminus of the parent CXCR3 ligand from P or A to F, G, I, K, L, M, T, V, W, or Y;
- (2) further adding A, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y to the N-terminus of the parent CXCR3 ligand;
- (3) inserting A, F, G, H, I, K, L, M, P, Q, R, S, T, V, W, or Y between the 1st and 2nd amino acids at the N-terminus of the parent CXCR3 ligand;
- and
- (4) deleting the V at the N-terminus of the parent CXCR3 ligand.
A method of producing a CXCR3 ligand having resistance to DPPIV, wherein the method comprises modifying a parent CXCR3 ligand in which the 2nd amino acid from the N-terminus is P, wherein the method comprises at least one of the following:
- (1) further adding A, D, E, F, G, H, I, K, L, M, N, P, Q, S, T, V, W, or Y to the N-terminus of the parent CXCR3 ligand;
- (2) substituting the 2nd amino acid from the N-terminus of the parent CXCR3 ligand from P to A, D, E, G, H, I, M, N, Q, R, S, T, V, W, or Y;
- and
- (3) inserting A, D, E, F, G, H, L, M, N, P, Q, S, T, W, or Y between the 1st and 2nd amino acids at the N-terminus of the parent CXCR3 ligand.
Dependencies are inferred from the claim text.