Compositions and Methods for Targeted Delivery of TGFß

Abstract

The present disclosure provides a polypeptide complex comprising a target-binding polypeptide that binds a molecule on a target cell or a molecule in an extracellular matrix (ECM), and a small latent complex comprising, in particular, a dimeric latency associated polypeptide (LAP), or a fragment or derivative thereof, and a dimeric mature Transforming Growth Factor β (TGFP) family polypeptide, or a fragment or derivative thereof. Further provided are polypeptides (e.g., fusion polypeptides), as well as related polynucleotides, vectors, cells, and pharmaceutical compositions. Methods for treating subjects using, e.g., the polypeptide complexes and/or fusion polypeptides, or pharmaceutical compositions thereof, are also provided.

Dependencies are inferred from the claim text.