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US 2026/0217767 A1Published application
Novel a4b7 thioether peptide dimer antagonists
AssigneeProtagonist Therapeutics, Inc.
InventorsAshok BHANDARI, Dinesh V. PATEL, Genet ZEMEDE, Brian Troy FREDERICK, Larry C. MATTHEAKIS, David LIU
Life of this patent
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Abstract
The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of α4β7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.
Claims9
-46. (canceled)
A peptide molecule comprising a sequence selected from the group consisting of:
- SEQ ID NO:
- 151, 152, 158, 159, 164, 165, 169, 228, and 229.
A peptide molecule comprising a peptide consisting of a sequence selected from the group consisting of:
- SEQ ID NO:
- 151, 152, 158, 159, 164, 165, 169, 228, and 229.
Dependencies are inferred from the claim text.