Solid phase peptide synthesis (spps) solvent system
AssigneeRoche Diagnostics Operations, Inc.
InventorsLars Hillringhaus, Nils Winter
Life of this patent
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Abstract
The present invention relates to a solid phase peptide synthesis (SPPS) solvent system and use thereof. The present invention further relates to a solid phase peptide synthesis (SPPS), a kit, a peptide synthesizer and the use thereof.
Claims15
A solid phase peptide synthesis (SPPS) solvent system comprising or consisting of a solvent mixture, wherein the solvent mixture comprises or consists of a first component, a second component and optionally a third component,
- wherein the first component is acetonitrile (MeCN),
- wherein the second component is dimethylsulfoxide (DMSO) or a tetrahydrofuran based solvent, and wherein the third component is the tetrahydrofuran based solvent in case of the second component is dimethylsulfoxide or wherein the third component is dimethylsulfoxide in case of the second component is the tetrahydrofuran based solvent.
The SPPS solvent system of claim 2, wherein said solvent system or solvent mixture is free of a solvent, which is selected from a group consisting of N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA), N-methyl-2-pyrrolidon (NMP), dichloromethane (DCM) and mixtures thereof.
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Dependencies are inferred from the claim text.