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US 2026/0217754 A1Published application
Modified glucocorticoids
AssigneeBoard of Regents, The University of Texas System
InventorsThomas J. Slaga, Daniel Glade, Anna Mancha Ramirez, Huiyun Liang, Rita Ghosh
Life of this patent
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Abstract
Certain embodiments are directed to modified glucocorticoid compounds having one or both of (i) a substitution of a halogen for the 11 hydroxy and/or (ii) reduction of the bond between carbon 4 and carbon 5 of the A ring.
Claims8
A modified glucocorticoid compound having a structure of Formula I
- where:
- a bond between carbon one and carbon two is saturated or is a double bond;
- R1 is selected from hydrogen, hydroxyl, C1 to C3 alkyl, C1 to C3 alcohol, ester, substituted ester, ether, substituted ether, C1 to C3 carboxylic acid, ketone, substituted ketone, C1 to C3 amide, or C1 to C3 aldehyde group. In certain aspects the substitution is an alkyl, alkoxy, hydroxyl, sulfhydryl, of amide;
- R2 is selected from hydrogen, hydroxyl, C1 to C3 alkyl, C1 to C3 alcohol, ester, substituted ester, ether, substituted ether, C1 to C3 carboxylic acid, C3 to C5 ketone, C3 to C5 substituted ketone, C1 to C3 amide, or C1 to C3 aldehyde group. In certain aspects the substitution is an alkyl, alkoxy, hydroxyl, sulfhydryl, of amide;
- R3 is selected from hydrogen, halogen, or hydroxyl;
- R4 is selected from hydrogen, halogen, or hydroxyl, wherein R3 and R4 optionally form a 5 or 6 member cycloalkyl or heterocycle;
- R5 and R6 are independently selected from hydrogen, hydroxide, fluorine, chlorine, bromine, or iodine;
- and
- X is a halogen.
6 more elements
A modified glucocorticoid compound having a structure of Formula II
- where:
- a bond between carbon one and carbon two is saturated or is a double bond;
- R1 is selected from hydrogen, hydroxyl, C1 to C3 alkyl, C1 to C3 alcohol, ester, substituted ester, ether, substituted ether, C1 to C3 carboxylic acid, ketone, substituted ketone, C1 to C3 amide, or C1 to C3 aldehyde group. In certain aspects the substitution is an alkyl, alkoxy, hydroxyl, sulfhydryl, of amide;
- R2 is selected from hydrogen, hydroxyl, C1 to C3 alkyl, C1 to C3 alcohol, ester, substituted ester, ether, substituted ether, C1 to C3 carboxylic acid, ketone, substituted ketone, C1 to C3 amide, or C1 to C3 aldehyde group. In certain aspects the substitution is an alkyl, alkoxy, hydroxyl, sulfhydryl, of amide;
- R3 is selected from hydrogen, halogen, or hydroxyl;
- R4 is selected from hydrogen, halogen, or hydroxyl, wherein R3 and R4 optionally form a 5 or 6 member cycloalkyl or heterocycle;
- R5 and R6 are independently selected from hydrogen, hydroxide, fluorine, chlorine, bromine, or iodine;
- and
- X is a halogen.
6 more elements
Dependencies are inferred from the claim text.