Synthesis of Fosfomycin Disodium

Synthesis process for obtaining disodium fosfomycin, comprising the steps of:

• a) preparing a homogeneous solution of sodium hydroxide in methanol at a temperature 12±2° C. with water/ice bath;
• b) carrying out the reaction of the homogeneous solution of sodium hydroxide with fosfomycin phenylethylamine, at a temperature of 12±2° C. for 30 minutes;
• c) adding anhydrous ethanol in a time of 30 to 40 minutes at a temperature of 8°±2° C.;
• and maintaining the suspension in agitation for an additional time of 30 minutes at 8°±2° C.;
• filtering the suspension to obtain a cake, the cake is washed twice with anhydrous ethanol under nitrogen atmosphere;
• d) mixing the solid with anhydrous ethanol at a temperature of 20°±2° C., and it is maintained in vigorous agitation for 30 minutes at 20°±2° C.;
• filter the suspension under nitrogen atmosphere;
• make two washes to the cake with anhydrous ethanol and two washes to the cake with acetone;
• e) drying the product under vacuum at a temperature of 35°±2° C. overnight;
• pack under nitrogen atmosphere;
• and
• f) storing in polyethylene and aluminum bags with nitrogen and one or more drying agents.