Crystalline forms of antioxidant compound
AssigneeMitotech SA
InventorsMaxim SKULACHEV, Tatiana ZINEVICH, Olga KIRICHENKO, Anton PETROV, Vadim TASHLITSKY
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Abstract
Novel crystalline forms of halide salts of 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium, such as the bromide, chloride, and iodide salts, are provided. Also provided are industrially feasible methods for manufacture of the crystalline forms with high purity.
Claims22
A crystalline form of a halide salt of the compound 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium.
A method for preparation of a crystalline form of a halide salt of the compound 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium, such as the bromide or chloride or iodide salt, the method comprising:
- (a) providing an alcoholic solution of a halide salt of 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium;
- (b) adding a crystallization solvent to the alcoholic solution, wherein the crystallization solvent is selected from the group consisting of an ether and an ester;
- and
- (c) removing the alcohol and the crystallization solvent to obtain the crystalline form.
A composition comprising a halide salt of 2,3-dimethyl-1,4-benzoquinone-5-decyl-triphenylphosphonium, such as a bromide or chloride or iodide salt, at a purity of greater than 98% by weight.
Dependencies are inferred from the claim text.